Beta-Alanine. The Facts.

Research

Med Sci Sports Exerc. 2011 Mar 10. [Epub ahead of print]
Effect of B-Alanine plus Sodium Bicarbonate on High-Intensity Cycling Capacity.
Sale C, Saunders B, Hudson S, Wise JA, Harris RC, Sunderland CD.
1Biomedical, Life and Health Sciences Research Centre, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK. 2National Alternatives International, Linda Vista Drive, San Marcos, California, CA92078, U.S.A.

Abstract
PURPOSE:We examined the effect of B-alanine supplementation plus sodium bicarbonate on high-intensity cycling capacity.
METHODS:Twenty males (age 25±5y; height 1.79±0.06 m; body mass 80.0±10.3 kg) were assigned to either a placebo (P) or a B-alanine (BA, 6.4 g·d over 4 wks) group based upon powermax, completing four cycling capacity tests at 110% of powermax (CCT110%) to determine time to exhaustion (TTE) and total work done (TWD). A CCT110% was performed twice (habituation and baseline) pre-supplementation (with maltodextrin [MD]) and twice post-supplementation (with MD and with sodium bicarbonate [SB]), using a crossover design with 2 days rest between trials, creating four study conditions (PMD, PSB, BAMD, BASB). Blood lactate, bicarbonate, pH and base excess were determined at baseline, pre-exercise, immediately post-exercise and 5 minutes post-exercise. Data were analyzed using repeated measures ANOVA.
RESULTS:TTE was increased in all conditions post-supplementation (+1.6% PMD, +6.5% PSB, +12.1% BAMD, +16.2% BASB). Both BAMD and BASB resulted in significantly improved TTE compared with pre-supplementation (P?0.01). Although further increases in TTE (4.1%) were shown in BASB compared to BAMD, these differences were not significant (P=0.74). Differences in TWD were similar to those of TTE. Blood bicarbonate concentrations were significantly (P?0.001) elevated prior to exercise in PSB and BASB but not in PMD or BAMD. Blood lactate concentrations were significantly elevated following exercise, remaining elevated after 5 minutes of recovery (P?0.001) and were highest in PSB and BASB.
CONCLUSIONS:Results show that BA improved high-intensity cycling capacity. However, despite a 6 s (~4%) increase in TTE with the addition of SB, this did not reach statistical significance, but magnitude-based inferences suggested a ~70% probability of a meaningful positive difference.

J Appl Physiol. 2010 Oct;109(4):1096-101. Epub 2010 Jul 29.
Important role of muscle carnosine in rowing performance.
Baguet A, Bourgois J, Vanhee L, Achten E, Derave W.
Dept. of Movement and Sports Sciences, Ghent Univ., Watersportlaan 2, B-9000 Ghent, Belgium.

Abstract
The role of the presence of carnosine (B-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood. Chronic oral B-alanine supplementation is shown to elevate muscle carnosine content and improve anaerobic exercise performance during some laboratory tests, mainly in the untrained. It remains to be determined whether carnosine loading can improve single competition-like events in elite athletes. The aims of the present study were to investigate if performance is related to the muscle carnosine content and if B-alanine supplementation improves performance in highly trained rowers. Eighteen Belgian elite rowers were supplemented for 7 wk with either placebo or B-alanine (5 g/day). Before and following supplementation, muscle carnosine content in soleus and gastrocnemius medialis was measured by proton magnetic resonance spectroscopy ((1)H-MRS) and the performance was evaluated in a 2,000-m ergometer test. At baseline, there was a strong positive correlation between 100-, 500-, 2,000-, and 6,000-m speed and muscle carnosine content. After B-alanine supplementation, the carnosine content increased by 45.3% in soleus and 28.2% in gastrocnemius. Following supplementation, the B-alanine group was 4.3 s faster than the placebo group, whereas before supplementation they were 0.3 s slower (P = 0.07). Muscle carnosine elevation was positively correlated to 2,000-m performance enhancement (P = 0.042 and r = 0.498). It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and the positive correlation between changes in muscle carnosine and performance improvement suggest that muscle carnosine is a new determinant of rowing performance.

Abstract
The role of the presence of carnosine (B-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood. Chronic oral B-alanine supplementation is shown to elevate muscle carnosine content and improve anaerobic exercise performance during some laboratory tests, mainly in the untrained. It remains to be determined whether carnosine loading can improve single competition-like events in elite athletes. The aims of the present study were to investigate if performance is related to the muscle carnosine content and if B-alanine supplementation improves performance in highly trained rowers. Eighteen Belgian elite rowers were supplemented for 7 wk with either placebo or B-alanine (5 g/day). Before and following supplementation, muscle carnosine content in soleus and gastrocnemius medialis was measured by proton magnetic resonance spectroscopy ((1)H-MRS) and the performance was evaluated in a 2,000-m ergometer test. At baseline, there was a strong positive correlation between 100-, 500-, 2,000-, and 6,000-m speed and muscle carnosine content. After B-alanine supplementation, the carnosine content increased by 45.3% in soleus and 28.2% in gastrocnemius. Following supplementation, the B-alanine group was 4.3 s faster than the placebo group, whereas before supplementation they were 0.3 s slower (P = 0.07). Muscle carnosine elevation was positively correlated to 2,000-m performance enhancement (P = 0.042 and r = 0.498). It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and the positive correlation between changes in muscle carnosine and performance improvement suggest that muscle carnosine is a new determinant of rowing performance.

J Strength Cond Res. 2010 May;24(5):1199-207.
Six weeks of high-intensity interval training with and without beta-alanine supplementation for improving cardiovascular fitness in women.Walter AA, Smith AE, Kendall KL, Stout JR, Cramer JT.
Biophysics Laboratory, Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma, USA.

Abstract
The purpose of the present study was to evaluate the effects of cycle ergometry high-intensity interval training (HIIT) with and without beta-alanine supplementation on maximal oxygen consumption rate (VO2 peak), cycle ergometer workload at the ventilatory threshold (VT W), and body composition. Forty-four women (mean +/- SD age = 21.8 +/- 3.7 years; height = 166.5 +/- 6.6 cm; body mass (BM) = 65.9 +/- 10.8 kg; VO2 peak = 31.5 +/- 6.2 ml x kg(-1) x min(-1)) were randomly assigned to 1 of 3 groups: beta-alanine (BA, n = 14) 1.5 g + 15 g dextrose powder; placebo (PL, n = 19) 16.5 g dextrose powder; or control (CON, n = 11). Testing was conducted at baseline (week 0), after 3 weeks (week 4), and after 6 weeks (week 8). VO2 peak (ml x kg(-1) x min(-1)) and VT W were measured with a metabolic cart during graded exercise tests on a corival cycle ergometer, and body composition (percent fat = % fat and fat-free mass = FFM) were determined by air displacement plethysmography. High-intensity interval training was performed on a corival cycle ergometer 3 times per week with 5 2-minute work intervals and 1-minute passive recovery with undulating intensities (90-110% of the workload recorded at VO2 peak) during each training session. VO2 peak increased (p 0.05) for the CON group. VT W increased (p

J Int Soc Sports Nutr. 2009 Feb 11;6:5.
Effects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial.
Smith AE, Walter AA, Graef JL, Kendall KL, Moon JR, Lockwood CM, Fukuda DH, Beck TW, Cramer JT, Stout JR.
Metabolic and Body Composition Laboratory, Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019, USA. jrstout@ou.edu.

ABSTRACT: BACKGROUND: Intermittent bouts of high-intensity exercise result in diminished stores of energy substrates, followed by an accumulation of metabolites, promoting chronic physiological adaptations. In addition, beta-alanine has been accepted has an effective physiological hydrogen ion (H+) buffer. Concurrent high-intensity interval training (HIIT) and beta-alanine supplementation may result in greater adaptations than HIIT alone. The purpose of the current study was to evaluate the effects of combining beta-alanine supplementation with high-intensity interval training (HIIT) on endurance performance and aerobic metabolism in recreationally active college-aged men. METHODS: Forty-six men (Age: 22.2 +/- 2.7 yrs; Ht: 178.1 +/- 7.4 cm; Wt: 78.7 +/- 11.9; VO2peak: 3.3 +/- 0.59 l.min-1) were assessed for peak O2 utilization (VO2peak), time to fatigue (VO2TTE), ventilatory threshold (VT), and total work done at 110% of pre-training VO2peak (TWD). In a double-blind fashion, all subjects were randomly assigned into one either a placebo (PL - 16.5 g dextrose powder per packet; n = 18) or beta-alanine (BA - 1.5 g beta-alanine plus 15 g dextrose powder per packet; n = 18) group. All subjects supplemented four times per day (total of 6 g/day) for the first 21-days, followed by two times per day (3 g/day) for the subsequent 21 days, and engaged in a total of six weeks of HIIT training consisting of 5-6 bouts of a 2:1 minute cycling work to rest ratio. RESULTS: Significant improvements in VO2peak, VO2TTE, and TWD after three weeks of training were displayed (p < 0.05). Increases in VO2peak, VO2TTE, TWD and lean body mass were only significant for the BA group after the second three weeks of training. CONCLUSION: The use of HIIT to induce significant aerobic improvements is effective and efficient. Chronic BA supplementation may further enhance HIIT, improving endurance performance and lean body mass.

Med Sci Sports Exerc. 2009 Apr;41(4):898-903.
Beta-alanine improves sprint performance in endurance cycling.
Van Thienen R, Van Proeyen K, Vanden Eynde B, Puype J, Lefere T, Hespel P.
Department of Biomedical Kinesiology, Research Centre for Exercise and Health, Katholieke Universiteit Leuven, Leuven, Belgium.

Abstract
PURPOSE: Recent research has shown that chronic dietary beta-alanine (betaALA) supplementation increases muscle carnosine content, which is associated with better performance in short (1-2 min) maximal exercise. Success in endurance competitions often depends on a final sprint. However, whether betaALA can be ergogenic in sprint performance at the end of an endurance competition is at present unknown. Therefore, we investigated the effect of 8-wk betaALA administration in moderately to well-trained cyclists on sprint performance at the end of a simulated endurance cycling race. METHODS: A double-blind study was performed, which consisted of two experimental test sessions interspersed by an 8-wk betaALA (2-4 g.d; n = 9) or matched placebo (PL; n = 8) supplementation period. In the pretesting and the posttesting, subjects performed a 10-min time trial and a 30-s isokinetic sprint (100 rpm) after a 110-min simulated cycling race. Capillary blood samples were collected for determination of blood lactate concentration and pH. RESULTS: Mean power output during the time trial was approximately 300 W and was similar between PL and betaALA during either the pretesting or the posttesting. However, compared with PL, during the final sprint after the time trial, betaALA on average increased peak power output by 11.4% (95% confidence interval = +7.8 to +14.9%, P = 0.0001), whereas mean power output increased by 5.0% (95% confidence interval = +2.0 to +8.1%, P = 0.005). Blood lactate and pH values were similar between groups at any time. CONCLUSION: Oral betaALA supplementation can significantly enhance sprint performance at the end of an exhaustive endurance exercise bout.

PURPOSE: Recent research has shown that chronic dietary beta-alanine (betaALA) supplementation increases muscle carnosine content, which is associated with better performance in short (1-2 min) maximal exercise. Success in endurance competitions often depends on a final sprint. However, whether betaALA can be ergogenic in sprint performance at the end of an endurance competition is at present unknown. Therefore, we investigated the effect of 8-wk betaALA administration in moderately to well-trained cyclists on sprint performance at the end of a simulated endurance cycling race. METHODS: A double-blind study was performed, which consisted of two experimental test sessions interspersed by an 8-wk betaALA (2-4 g.d n = 9) or matched placebo (PL n = 8 ) supplementation period. In the pretesting and the posttesting, subjects performed a 10-min time trial and a 30-s isokinetic sprint (100 rpm) after a 110-min simulated cycling race. Capillary blood samples were collected for determination of blood lactate concentration and pH. RESULTS: Mean power output during the time trial was approximately 300 W and was similar between PL and betaALA during either the pretesting or the posttesting. However, compared with PL, during the final sprint after the time trial, betaALA on average increased peak power output by 11.4% (95% confidence interval = +7.8 to +14.9%, P = 0.0001), whereas mean power output increased by 5.0% (95% confidence interval = +2.0 to +8.1%, P = 0.005). Blood lactate and pH values were similar between groups at any time. CONCLUSION: Oral betaALA supplementation can significantly enhance sprint performance at the end of an exhaustive endurance exercise bout.

Journal of the International Society of Sports Nutrition 2008, 5(Suppl 1):P5doi:10.1186/1550-2783-5-S1-P5
Beta-alanine supplementation and high-intensity interval training augments metabolic adaptations and endurance performance in college-aged men
Abbie E Smith email, Ashley A Walter, Kristina L Kendall, Jennifer L Graef, Christopher M Lockwood, Jordan R Moon, Travis W Beck, Joel T Cramer and Jeffery R Stout FISSN Department of Health & Exercise Science, University of Oklahoma, Norman, OK, USA

Background-A randomized, double-blind, placebo-controlled study was conducted to evaluate the effects Î²-alanine supplementation and high-intensity interval training (HIIT) on endurance performance.

Methods-Forty-six college-aged men (Age: 22.2 Â± 3.3 yrs, VO2peak: 42.6 Â± 6.2 mlÂ·kgÂ·min-1, 3.3 Â± 0.6 lÂ·min-1) volunteered to participate. In a random fashion, all subjects were placed into one of three groups: placebo (PL â€“ 16.5 g of flavored dextrose powder per packet; n = 18), Î²-alanine (BA â€“ 1.5 g Î²-alanine plus 15 g of flavored dextrose powder per packet; n = 18) or control (n = 10) groups. Each treatment group ingested one packet 4 times per day (total of 6 g/day) for the first 21-day adaptation phase, followed by 2 times per day (3 g/day) for the subsequent 21 days. All participants performed a continuous VO2peak test on a cycle ergometer (Corval Lode, Gronigen, the Netherlands) which was further used to establish ventilatory threshold (VT),
and total time to exhaustion (VO2TTE, seconds) at pre-, mid- and post-testing. Total work done (TWD) was also measured, calculated from the totaltime (T; seconds) completed at a workload corresponding to 110% of their maximal power output (watt, W) determined from the VO2peak test [TWD (kJ) = (T Ã— W)/1000]. Following initial testing, all participants in the BA and PL groups engaged in a 3 week supplementing and training adaptation phase. Each training session in the adaptation phase consisted of 5 bouts of a 2:1 minute cycling work to rest ratio, introduced in an undulating progression starting at 90% VO2peak power output and reaching 110%. The second 3 week training phase progressed, reaching intensities up to 115% of VO2peak. Body composition was assessed using air displacement plethysmography (Bod PodÂ®) at pre- mid- and post-testing. Separate one-way analyses of covariance were used to identify and group (BA vs. PL. vs. CON) Ã— time (Mid- vs. Post-) interactions, adjusting mean post-test values for differences in the mid-test scores, due to the supplementing and training adaptation phase.

Results-There was a significant difference among all post-test GXT variables (VO2peak, VO2TTE, and VT) and TWD, after adjusting for the mid-test adaptation values (p â‰¤ 0.000). However, there were no differences between treatment group means. Individual responses indicated a greater number of the BA participants improving in VO2peak (83%) and VO2TTE (72%) performance over the PL group (61% and 56%, respectively). Furthermore, bonferroni-corrected post-hoc pairwise comparisons indicated the significant increases in TWD were greater for the BA group than the CON (p = 0.029). There were no significant changes in body composition following training and supplementing.

Conclusion-Three weeks of combined Î²-alanine supplementation and HIIT, following a 21-day Î²-alanine loading and HIIT adaptation phase, significantly improves aerobic performance. The improvements in performance may be attributed to a greater reliance on aerobic metabolism due to chronic adaptations to HIIT, in combination with an improved muscle buffering capacity as a result of an increase in intramuscular carnosine levels.

Nutr Res. 2008 Jan;28(1):31-5.
Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players.Hoffman JR, Ratamess NA, Faigenbaum AD, Ross R, Kang J, Stout JR, Wise JA.
Department of Health and Exercise Science, The College of New Jersey, PO Box 7718, Ewing, NJ 08628, USA. hoffmanj@tcnj.edu
Abstract

The purpose of this study was to examine the effect of 30 days of beta-alanine supplementation in collegiate football players on anaerobic performance measures. Subjects were randomly divided into a supplement (beta-alanine group [BA], 4.5 g x d(-1) of beta-alanine) or placebo (placebo group [P], 4.5 g x d(-1) of maltodextrin) group. Supplementation began 3 weeks before preseason football training camp and continued for an additional 9 days during camp. Performance measures included a 60-second Wingate anaerobic power test and 3 line drills (200-yd shuttle runs with a 2-minute rest between sprints) assessed on day 1 of training camp. Training logs recorded resistance training volumes, and subjects completed questionnaires on subjective feelings of soreness, fatigue, and practice intensity. No difference was seen in fatigue rate in the line drill, but a trend (P = .07) was observed for a lower fatigue rate for BA compared with P during the Wingate anaerobic power test. A significantly higher training volume was seen for BA in the bench press exercise, and a trend (P = .09) for a greater training volume was seen for all resistance exercise sessions. In addition, subjective feelings of fatigue were significantly lower for BA than P. In conclusion, despite a trend toward lower fatigue rates during 60 seconds of maximal exercise, 3 weeks of beta-alanine supplementation did not result in significant improvements in fatigue rates during high-intensity anaerobic exercise. However, higher training volumes and lower subjective feelings of fatigue in BA indicated that as duration of supplementation continued, the efficacy of beta-alanine supplementation in highly trained athletes became apparent.PMID: 19083385 [PubMed - indexed for MEDLINE]

Beta-Alanine and the Hormonal Response to Exercise.
Hoffman J, Ratamess NA, Ross R, Kang J, Magrelli J, Neese K, Faigenbaum AD, Wise JA.
Health and Exercise Science, The College of New Jersey, Ewing, New Jersey, United States.
Int J Sports Med. 2008 Jun 11. [Epub ahead of print]

The effect of 30 days of beta-alanine supplementation (4.8 g per day) on resistance exercise performance and endocrine changes was examined in eight experienced resistance-trained men. An acute resistance exercise protocol consisting of 6 sets of 12 repetitions of the squat exercise at 70 % of one-repetition maximum (1-RM) with 1.5 minutes of rest between sets was performed before and after each supplemental period. Blood draws occurred at baseline (BL), immediate (IP), 15-minutes (15P) and 30-minutes (30P) postexercise for growth hormone, testosterone and cortisol concentrations. A 22 % (p < 0.05) difference in total number of repetitions performed at the end of 4 weeks of supplementation was seen between beta-alanine (BA) and placebo (PL), and Delta mean power was greater in BA (98.4 +/- 43.8 w) vs. PL (7.2 +/- 29.6 w). Growth hormone concentrations were elevated from BL at IP and 15P for both groups, while cortisol concentrations were greater than BL at all time points for both BA and PL. No group differences were noted. No change from BL was seen in testosterone concentrations for either group. Results indicate that four weeks of beta-alanine supplementation can significantly improve muscular endurance during resistance training in experienced resistance-trained athletes. However, these performance gains did not affect the acute endocrine response to the exercise stimulus.

J Int Soc Sports Nutr. 2008 Nov 7;5:21.
The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study.
Stout JR, Graves BS, Smith AE, Hartman MJ, Cramer JT, Beck TW, Harris RC.
Department of Health and Exercise Science, University of Oklahoma, Norman, OK, USA. jrstout@ou.edu.

ABSTRACT: BACKGROUND: Aging is associated with a significant reduction in skeletal muscle carnosine which has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the rate of fatigue during exercise. Supplementing beta-alanine has been shown to significantly increase skeletal muscle carnosine. The purpose of this study, therefore, was to examine the effects of ninety days of beta-alanine supplementation on the physical working capacity at the fatigue threshold (PWCFT) in elderly men and women. METHODS: Using a double-blind placebo controlled design, twenty-six men (n = 9) and women (n = 17) (age +/- SD = 72.8 +/- 11.1 yrs) were randomly assigned to either beta-alanine (BA: 800 mg x 3 per day; n = 12; CarnoSyntrade mark) or Placebo (PL; n = 14) group. Before (pre) and after (post) the supplementation period, participants performed a discontinuous cycle ergometry test to determine the PWCFT. RESULTS: Significant increases in PWCFT (28.6%) from pre- to post-supplementation were found for the BA treatment group (p < 0.05), but no change was observed with PL treatment. These findings suggest that ninety days of BA supplementation may increase physical working capacity by delaying the onset of neuromuscular fatigue in elderly men and women. CONCLUSION: We suggest that BA supplementation, by improving intracellular pH control, improves muscle endurance in the elderly. This, we believe, could have importance in the prevention of falls, and the maintenance of health and independent living in elderly men and women.
PMID: 18992136 [PubMed - in process]

J Appl Physiol. 2007 Nov;103(5):1736-43. Epub 2007 Aug 9.Click here to read Links
beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters.
Derave W, Ozdemir MS, Harris RC, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten E.
Dept. of Movement and Sport Sciences, Ghent Univ., Watersportlaan 2, B-9000 Ghent, Belgium. Wim.derave@ugent.be

Carnosine (beta-alanyl-l-histidine) is present in high concentrations in human skeletal muscle. The ingestion of beta-alanine, the rate-limiting precursor of carnosine, has been shown to elevate the muscle carnosine content. We aimed to investigate, using proton magnetic resonance spectroscopy (proton MRS), whether oral supplementation with beta-alanine during 4 wk would elevate the calf muscle carnosine content and affect exercise performance in 400-m sprint-trained competitive athletes. Fifteen male athletes participated in a placebo-controlled, double-blind study and were supplemented orally for 4 wk with either 4.8 g/day beta-alanine or placebo. Muscle carnosine concentration was quantified in soleus and gastrocnemius by proton MRS. Performance was evaluated by isokinetic testing during five bouts of 30 maximal voluntary knee extensions, by endurance during isometric contraction at 45% maximal voluntary contraction, and by the indoor 400-m running time. beta-Alanine supplementation significantly increased the carnosine content in both the soleus (+47%) and gastrocnemius (+37%). In placebo, carnosine remained stable in soleus, while a small and significant increase of +16% occurred in gastrocnemius. Dynamic knee extension torque during the fourth and fifth bout was significantly improved with beta-alanine but not with placebo. Isometric endurance and 400-m race time were not affected by treatment. In conclusion, 1) proton MRS can be used to noninvasively quantify human muscle carnosine content; 2) muscle carnosine is increased by oral beta-alanine supplementation in sprint-trained athletes; 3) carnosine loading slightly but significantly attenuated fatigue in repeated bouts of exhaustive dynamic contractions; and 4) the increase in muscle carnosine did not improve isometric endurance or 400-m race time.
PMID: 17690198 [PubMed - indexed for MEDLINE]

Amino Acids. 2007;32(3):381-6. Epub 2006 Nov 30.Click here to read Links
Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.
Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR, Harris RC, O'Kroy J.
Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019-6081, USA. jrstout@ou.edu

This study examined the effects of 28 days of beta-alanine supplementation on the physical working capacity at fatigue threshold (PWCFT), ventilatory threshold (VT), maximal oxygen consumption (VO2-MAX), and time-to-exhaustion (TTE) in women. Twenty-two women (age+/-SD 27.4+/-6.1 yrs) participated and were randomly assigned to either the beta-alanine (CarnoSyn) or Placebo (PL) group. Before (pre) and after (post) the supplementation period, participants performed a continuous, incremental cycle ergometry test to exhaustion to determine the PWCFT, VT, VO2-MAX, and TTE. There was a 13.9, 12.6 and 2.5% increase (p<0.05) in VT, PWCFT, and TTE, respectively, for the beta-alanine group, with no changes in the PL (p>0.05). There were no changes for VO2-MAX (p>0.05) in either group. Results of this study indicate that beta-alanine supplementation delays the onset of neuromuscular fatigue (PWCFT) and the ventilatory threshold (VT) at submaximal workloads, and increase in TTE during maximal cycle ergometry performance. However, beta-alanine supplementation did not affect maximal aerobic power (VO2-MAX). In conclusion, beta-alanine supplementation appears to improve submaximal cycle ergometry performance and TTE in young women, perhaps as a result of an increased buffering capacity due to elevated muscle carnosine concentrations.
PMID: 17136505 [PubMed - indexed for MEDLINE]

Amino Acids. 2007 Sep;33(3):505-10. Epub 2006 Sep 5.
Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion.
Zoeller RF, Stout JR, O’kroy JA, Torok DJ, Mielke M.
Department of Exercise Science and Health Promotion, Florida Atlantic University, Davie, FL, USA. rzoeller@fau.edu

The effect of beta-alanine (beta-Ala) alone or in combination with creatine monohydrate (Cr) on aerobic exercise performance is unknown. The purpose of this study was to examine the effects of 4 weeks of beta-Ala and Cr supplementation on indices of endurance performance. Fifty-five men (24.5 +/- 5.3 yrs) participated in a double-blind, placebo-controlled study and randomly assigned to one of 4 groups; placebo (PL, n = 13), creatine (Cr, n = 12), beta-alanine (beta-Ala, n = 14), or beta-alanine plus creatine (CrBA, n = 16). Prior to and following supplementation, participants performed a graded exercise test on a cycle ergometer to determine VO(2peak), time to exhaustion (TTE), and power output, VO(2), and percent VO(2peak) associated with VT and LT. No significant group effects were found. However, within groups, a significant time effect was observed for CrBa on 5 of the 8 parameters measured. These data suggest that CrBA may potentially enhance endurance performance.
PMID: 16953366 [PubMed - indexed for MEDLINE

Amino Acids. 2007 Feb;32(2):225-33. Epub 2006 Jul 28.
Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity.
Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA.
School of Sports, Exercise & Health Sciences, University of Chichester, Chichester, UK.

Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine total work done (TWD) at 110% (CCT(110%)) of their maximum power (Wmax). Twelve matched subjects received a placebo. Eleven of these completed the CCT(110%) at 0 and 4 wks, and 8, 10 wks. Muscle biopsies were obtained from 5 of the 8 and one additional subject. Muscle carnosine was significantly increased by +58.8% and +80.1% after 4 and 10 wks beta-alanine supplementation. Carnosine, initially 1.71 times higher in type IIa fibres, increased equally in both type I and IIa fibres. No increase was seen in control subjects. Taurine was unchanged by 10 wks of supplementation. 4 wks beta-alanine supplementation resulted in a significant increase in TWD (+13.0%); with a further +3.2% increase at 10 wks. TWD was unchanged at 4 and 10 wks in the control subjects. The increase in TWD with supplementation followed the increase in muscle carnosine.
PMID: 16868650 [PubMed - indexed for MEDLINE]

Amino Acids. 2006 Sep 5;
Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion.
Zoeller RF, Stout JR, O’kroy JA, Torok DJ, Mielke M.
Department of Exercise Science and Health Promotion, Florida Atlantic University, Davie, FL, U.S.A.

IJSNEM, 16(4), August 2006, Copyright Â© 2006
Effect of Creatine and Beta-Alanine Supplementation on Performance and Endocrine Responses in Strength/Power Athletes
Jay Hoffman; Nicholas A. Ratamess; Jie Kang; Gerald Mangine; Avery Faigenbaum; Jeffrey Stout
Full Article Table of Contents for Vol. 16, Iss. 4

Abstract
The effects of creatine and creatine plus beta-alanine on strength, power, body composition, and endocrine changes were examined during a 10-wk resistance training program in collegiate football players. Thirty-three male subjects were randomly assigned to either a placebo (P), creatine (C), or creatine plus beta-alanine (CA) group. During each testing session subjects were assessed for strength (maximum bench press and squat), power (Wingate anaerobic power test, 20-jump test), and body composition. Resting blood samples were analyzed for total testosterone, cortisol, growth hormone, IGF-1, and sex hormone binding globulin. Changes in lean body mass and percent body fat were greater (P < 0.05) in CA compared to C or P. Significantly greater strength improvements were seen in CA and C compared to P. Resting testosterone concentrations were elevated in C, however, no other significant endocrine changes were noted. Results of this study demonstrate the efficacy of creatine and creatine plus beta-alanine on strength performance. Creatine plus beta-alanine supplementation appeared to have the greatest effect on lean tissue accruement and body fat composition.

J Strength Cond Res. 2006 Nov;20(4):928-31.Links
Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold.
Stout JR, Cramer JT, Mielke M, O'Kroy J, Torok DJ, Zoeller RF.
Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019, USA. jrstout@ou.edu

The purpose of this study was to examine the effects of 28 days of beta-alanine (b-Ala) and creatine monohydrate (CrM) supplementation on the onset of neuromuscular fatigue by using the physical working capacity at neuromuscular fatigue threshold (PWC(FT)) test in untrained men. Fifty-one men (mean age +/- SD = 24.5 +/- 5.3 years) volunteered to participate in this 28-day, double-blind, placebo-controlled study and were randomly assigned to 1 of 4 groups: placebo (PLA; 34 g dextrose; n = 13), CrM (5.25 g CrM plus 34 g dextrose; n = 12), b-Ala (1.6 g b-Ala plus 34 g of dextrose; n = 12), or b-Ala plus CrM (CrBA; 5.25 g CrM plus 1.6 g b-Ala plus 34 g dextrose; n = 14). The supplement was ingested 4 times per day for 6 consecutive days, then twice per day for 22 days before posttesting. Before and after the supplementation, subjects performed a continuous incremental cycle ergometry test while a surface electromyographic signal was recorded from the vastus lateralis muscle to determine PWC(FT). The adjusted mean posttest PWC(FT) values (covaried for pretest PWC(FT) values) for the b-Ala and CrBA groups were greater than those for the PLA group (p < or = 0.05). However, there were no differences between the CrM vs. PLA, CrBA vs. b-Ala, CrM vs. b-Ala, or CrM vs. CrBA groups (p > 0.05). These findings suggested that b-Ala supplementation may delay the onset of neuromuscular fatigue. Furthermore, there appeared to be no additive or un

Int J Sport Nutr Exerc Metab. 2006 Aug;16(4):430-46.
Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes.
Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J.
Dept. of Health and Exercise Science, The College of New Jersey, Ewing, NJ 08628, USA.

The effects of creatine and creatine plus beta-alanine on strength, power, body composition, and endocrine changes were examined during a 10-wk resistance training program in collegiate football players. Thirty-three male subjects were randomly assigned to either a placebo (P), creatine (C), or creatine plus beta-alanine (CA) group. During each testing session subjects were assessed for strength (maximum bench press and squat), power (Wingate anaerobic power test, 20-jump test), and body composition. Resting blood samples were analyzed for total testosterone, cortisol, growth hormone, IGF-1, and sex hormone binding globulin. Changes in lean body mass and percent body fat were greater (P < 0.05) in CA compared to C or P. Significantly greater strength improvements were seen in CA and C compared to P. Resting testosterone concentrations were elevated in C, however, no other significant endocrine changes were noted. Results of this study demonstrate the efficacy of creatine and creatine plus beta-alanine on strength performance. Creatine plus beta-alanine supplementation appeared to have the greatest effect on lean tissue accruement and body fat composition.PMID: 17136944 [PubMed - indexed for MEDLINE

Amino Acids. 2006 May;30(3):279-89. Epub 2006 Mar 24.
The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis.
Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA.
School of Sports, Exercise and Health Sciences, University College Chichester, West Sussex, Chichester, UK. r.harris@ucc.ac.uk

Beta-alanine in blood-plasma when administered as A) histidine dipeptides (equivalent to 40 mg . kg(-1) bwt of beta-alanine) in chicken broth, or B) 10, C) 20 and D) 40 mg . kg(-1) bwt beta-alanine (CarnoSyn, NAI, USA), peaked at 428 +/- SE 66, 47 +/- 13, 374 +/- 68 and 833 +/- 43 microM. Concentrations regained baseline at 2 h. Carnosine was not detected in plasma with A) although traces of this and anserine were found in urine. Loss of beta-alanine in urine with B) to D) was <5%. Plasma taurine was increased by beta-alanine ingestion but this did not result in any increased loss via urine. Pharmacodynamics were further investigated with 3 x B) per day given for 15 d. Dietary supplementation with I) 3.2 and II) 6.4 g . d(-1) beta-alanine (as multiple doses of 400 or 800 mg) or III) L-carnosine (isomolar to II) for 4 w resulted in significant increases in muscle carnosine estimated at 42.1, 64.2 and 65.8%.PMID: 16554972 [PubMed - indexed for MEDLINE]

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